Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences A Randomized Clinical Trial

Wald Anna; Timmler Burkhard; Magaret Amalia; Warren Terri; Tyring Stephen; Johnston Christine; Fife Kenneth; Selke Stacy; Huang Meei-Li; Stobernack Hans-Peter; Zimmermann Holger; Corey Lawrence; Birkmann Alexander; Ruebsamen-Schaeff Helga

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Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences A Randomized Clinical Trial

机译：Pritelivir与Valacyclovir对比对经常复发患者生殖器HSV-2脱落的影响-一项随机临床试验

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IMPORTANCE Current therapy of herpes infections relies on nucleoside analogues. Pritelivir is a well-tolerated novel herpes simplex virus (HSV) helicase-primase inhibitor that reduced genital shedding and lesions.

机译：重要当前疱疹感染的治疗依赖于核苷类似物。 Pritelivir是一种耐受良好的新型单纯疱疹病毒（HSV）解旋酶-引发酶抑制剂，可减少生殖器脱落和病变。

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《JAMA: the Journal of the American Medical Association》 |2016年第23期|共9页
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Wald Anna; Timmler Burkhard; Magaret Amalia; Warren Terri; Tyring Stephen; Johnston Christine; Fife Kenneth; Selke Stacy; Huang Meei-Li; Stobernack Hans-Peter; Zimmermann Holger; Corey Lawrence; Birkmann Alexander; Ruebsamen-Schaeff Helga;
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1. Effect of pritelivir compared with valacyclovir on genital HSV-2 shedding in patients with frequent recurrences: a randomized clinical trial (vol 316, pg 2495, 2016) [J] . Wald A., Timmler B., Magaret A. JAMA: the Journal of the American Medical Association . 2017,第6期

机译：与Valacyclovir对常急复发患者生殖器HSV-2脱落的影响：随机临床试验（Vol 316，PG 2495,2016）
2. Effect of valacyclovir on viral shedding in immunocompetent patients with recurrent herpes simplex virus 2 genital herpes: a US-based randomized, double-blind, placebo-controlled clinical trial. [J] . Fife KH, Warren TJ, Ferrera RD, Mayo Clinic Proceedings . 2006,第10期

机译：伐昔洛韦对具有免疫能力的复发性单纯疱疹病毒2生殖器疱疹患者免疫脱落的影响：一项基于美国的随机，双盲，安慰剂对照临床试验。
3. Evaluation of the activity and safety of CS 21 barrier genital gel? compared to topical aciclovir and placebo in symptoms of genital herpes recurrences: A randomized clinical trial [J] . KhemisA., DuteilL., TilletY., Journal of the European Academy of Dermatology and Venereology: JEADV . 2014,第9期

机译：评估CS 21屏障生殖器凝胶的活性和安全性？与外用阿昔洛韦和安慰剂比较生殖器疱疹复发的症状：一项随机临床试验
4. TRANSFUSION-ASSOCIATED IMMUNODULATION IN CANCER RECURRENCE AND POSTOPERATIVE INFECTION: META-ANALYSES OF RANDOMISED CONTROLLED CLINICAL TRIALS [C] . International Symposium on Blood Transfusion . 1999

机译：癌症复杂相关免疫调节和术后感染：随机对照临床试验的荟萃分析
5. Effect of oral and gel tenofovir on genital HSV-2 shedding in immunocompetent women. [D] . Bender Ignacio, Rachel A. 2014

机译：口服和凝胶替诺福韦对具有免疫功能的女性生殖器HSV-2脱落的影响。
6. Editors Choice: High-dose Valacyclovir HSV-2 Suppression Results in Greater Reduction in Plasma HIV-1 Levels Compared With Standard Dose Acyclovir Among HIV-1/HSV-2 Coinfected Persons: A Randomized Crossover Trial [O] . Kenneth Mugwanya, Jared M. Baeten, Nelly R. Mugo, -1

机译：编辑推荐：在HIV-1 / HSV-2合并感染者中大剂量伐昔洛韦HSV-2抑制与标准剂量阿昔洛韦相比可更大程度地降低血浆HIV-1水平：一项随机交叉试验
7. Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences A Randomized Clinical Trial [O] . Wald Anna, Timmler Burkhard, Magaret Amalia, 2016

机译：Pritelivir与Valacyclovir相比对经常复发患者生殖器HSV-2脱落的影响随机临床试验
8. Randomized, Double-Blind Trial of Valacyclovir Prophylaxis for Cytomegalovirus Disease in Patients with Advanced Human Immunodeficiency Virus Infection (ACTG 204) Documentation [R] . 1994

机译：晚期人类免疫缺陷病毒感染患者巨细胞病毒病毒的伐昔洛韦预防随机双盲试验（aCTG 204）文献

Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences A Randomized Clinical Trial

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