Recurrence of stevens-johnson syndrome and toxic epidermal necrolysis

摘要

Dr Finkelstein and colleagues used hospital discharge data to determine the incidence and risk of recurrence of Stevens-Johnson syndrome and toxic epidermal necroly-sis, which are rare serious conditions. The authors did not review medical records. With expert review, only about 80% of prospectively ascertained cases diagnosed as Stevens-Johnson syndrome or toxic epidermal necrolysis had these diagnoses confirmed. The incidence of Stevens-Johnson syndrome and toxic epidermal necrolysis and the proportion of cases diagnosed as Stevens-Johnson syndrome in this study (750 hospitalized cases/13 million people over 10 years or 5.8 million person-years) are higher than in studies that included expert case review (0.4-1.2 per l million person-years for toxic epidermal necrolysis and 1-6 per l million person-years for Stevens-Johnson syndrome).