Patients' unrealistic hopes for cancer trial benefits may hinder consent.

摘要

Phase 1 and phase 2 trials ot therapies for cancers help provide necessary preliminary safety and effectiveness data, but they may offer limited therapeutic benefits to the patients enrolled in them. ' It is particularly important to ensure that patients with advanced cancers who have exhausted most other treatment options fully understand the purpose of phase 1 and phase 2 trials and that they may personally not benefit. However, some concerns have been raised about whether many participants have a complete understanding of the purpose of such studies or whether patients who participate hold unrealistic hopes that the intervention under study might help them.