Risk of blood clots higher for oral contraceptives with certain progestins.

摘要

Researchers analyzed Danish national registry data that included 8 million woman-years of observation from 2001 to 2009. They tracked information on how many prescriptions for oral contraceptives were filled, the types of estrogen andpro-gestin they contained and how long women used the products. Compared with women who did not use oral contraceptives, women who took products containing 30 ug to 40 ug of ethinyl estradiol with levonorgestrel were nearly 3 times more likely to develop venous thromboembolism. Women who used oral contraceptives with the same estrogen content but with desogestrel, gestodene, drospirenone, or cyproterone had a 6- to 7-fold increase in their risk of thromboembolism. No increased risk was found among women who used progestin-only pills or hormone-releasing intrauterine devices (Lidegaard O et al. BMJ. 2011;343: d6423. doi:10.1136/bmj.d6423).