Palladacycle promoted base controlled regio- and enantioselective hydrophosphination of 2-pyridylacrylate/amide and the cytotoxicity of their gold complexes

摘要

The regioselective asymmetric hydrophosphination of pyridine-functionalized alkenes can be achieved in the presence of stoichiometric amounts of the chiral palladium complex (R)-1. The presence or absence of base affords the respective beta- and alpha-adducts with excellent regiocontrol. Chiral gold-phosphine complexes incorporating the adducts exhibited good in vitro anticancer activity against the breast cancer cell line MDA-MB-231. Selectivity between the cancer cell line and normal cells was also observed.