Targeting cytotoxicity and tubulin polymerization by metal-carbene complexes on a purine tautomer platform

摘要

This communication describes the synthesis, structural investigation and tubulin binding of purine rare imino-tautomer based Ag(I) and Hg(II)-carbene complexes. These complexes exhibit cytotoxicity through tubulin interaction by binding to a site close to the GTP binding site.