SESTRIN 3 GENE REGULATES CONVULSIONS IN EPILEPSY

摘要

Epilepsy has a strong genetic component and susceptibility to the disease is influenced by hundreds of genes. Now, researchers have used a 'systems genetics' approach to determine how these genes work together to cause epilepsy. The team analysed hippocampal brain tissue samples from 129 people with temporal lobe epilepsy and found that genetic control of convulsions was due to a single gene, Sestrin 3 (SESN3), and publish their finding in Nature Communications (2015;6:6031).