A new,targeted RNA therapy has been shown to be effective in a mouse model of prostate cancer,according to research published online in Nature Biotechnology on 25 June(www.nature.com).US researchers combined two approaches to create a hybrid drug-a t

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Clinical question What is the effect of treating prehypertension with an angiotensin-receptor blocker?Bottom line This study tells us what we already know(that is,that blood pressure medicines reduce blood pressure),but says nothing about what really matters:does intervention in patients with prehypertension improve patient-oriented outcomes? The choice to study such an expensive drug(candesartan)is also disappointing,but not surprising.Given that the number needed to treat(NNT)to prevent one stroke,heart attack,or death in patients with mild hypertension is 140 for five years(www.jr2.ox.ac.uk/bandolier/index.html),it is likely that the actual clinical benefit of treating prehypertension is even smaller.