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Amphetamine derivatives could be useful in treating Parkinson's disease symptoms

机译:苯丙胺衍生物可用于治疗帕金森氏病症状

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Amphetamine-type drugs may be beneficial for treating symptoms of Parkinson's disease,according to new data from the US.Researchers developed mouse models of Parkinson's disease that were unable to produce or recycle dopamine.As expected,the Parkinson's symptoms were reversed by the administration of dopamine agonists and the dopamine precursor levodopa.However,a number of amphetamine derivatives were also found to reduce the akinesia and rigidity of the mice,via a mechanism not thought to involve dopamine.One drug,3,4-methylene-dioxymethamphetamine(MDMA),the chemical entity found in ecstasy,was found to be especially effective in restoring movement
机译:根据美国的新数据,苯丙胺类药物可能对治疗帕金森氏病的症状有益。研究人员开发了无法产生或回收多巴胺的帕金森氏病小鼠模型。多巴胺激动剂和多巴胺前体左旋多巴。但是,还发现许多苯丙胺衍生物通过一种不涉及多巴胺的机制降低了小鼠的运动能力和僵硬程度。一种药物,3,4-亚甲基-二氧基甲基苯丙胺(MDMA) ,发现摇头丸中的化学实体对恢复运动特别有效

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