Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis

摘要

Background Chronic kidney disease is characterised by low estimated glomerular filtration rate (eGFR) and highalbuminuria, and is associated with adverse outcomes. Whether these risks are modified by diabetes is unknown.Methods We did a meta-analysis of studies selected according to Chronic Kidney Disease Prognosis Consortium criteria. Data transfer and analyses were done between March, 2011, and June, 2012. We used Cox proportional hazards models to estimate the hazard ratios (HR) of mortality and end-stage renal disease (ESRD) associated with eGFR and albuminuria in individuals with and without diabetes.Findings We analysed data for 1024977 participants (128 505 with diabetes) from 30 general population and high-risk cardiovascular cohorts and 13 chronic kidney disease cohorts. In the combined general population and high-risk cohorts with data for all-cause mortality, 75 306 deaths occurred during a mean follow-up of 8 " 5 years (SD 5-0). In the 23 studies with data for cardiovascular mortality, 21237 deaths occurred from cardiovascular disease during a mean follow-up of 9-2 years (SD 4-9). In the general and high-risk cohorts, mortality risks were 1-2-1-9 times higher for participants with diabetes than for those without diabetes across the ranges of eGFR and albumin-to-creatinine ratio (ACR). With fixed eGFR and ACR reference points in the diabetes and no diabetes groups, HR of mortality outcomes according to lower eGFR and higher ACR were much the same in participants with and without diabetes (eg, for all-cause mortality at eGFR 45 mL/min per 1 " 73 m2 [vs 95 mL/min per 1 " 73 m2], HR 1-35; 95% CI 1-18-1-55; vs 1-33; 1-19-1-48 and at ACR 30 mg/g [vs 5 mg/g], 1-50; 1-35-1-65 vs 1-52; 1-38-1-67). The overall interactions were not significant. We identified much the same findings for ESRD in the chronic kidney disease cohorts.