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首页> 外文期刊>The Lancet >Should attenuated psychosis syndrome be included in DSM-5?
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Should attenuated psychosis syndrome be included in DSM-5?

机译:DSM-5是否应包括减毒性精神病综合症?

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摘要

We designed and synthesized phenolic BODIPY-containing antioxidants as traceable next-generation drug model named boron tracedrugs, UTX-42, UTX-43, and UTX-44. These drugs are basically composed of phenolic antioxidant moiety and stable boron-containing BODIPY moiety. Their antioxidant activities were evaluated by spectroscopic analysis with ABTS radical cations and inhibitory activity on lipid peroxidation of rat liver mitochondria. The reactivity of them with ABTS radical cations showed to be higher than trolox, which is one of the well-known antioxidants. These trace drugs, especially UTX-44, also showed much higher inhibitory activity than trolox against RLM lipid peroxidation. These results demonstrated that UTX-44 had the most potent boron-containing antioxidant among these drugs.
机译:我们设计并合成了含酚BODIPY的抗氧化剂,作为可追溯的下一代药物模型,称为硼微量药物,UTX-42,UTX-43和UTX-44。这些药物基本上由酚类抗氧化剂部分和稳定的含硼BODIPY部分组成。通过使用ABTS自由基阳离子光谱分析法评估了它们的抗氧化活性,以及​​对大鼠肝线粒体脂质过氧化的抑制活性。它们与ABTS自由基阳离子的反应性显示出高于trolox,后者是众所周知的抗氧化剂之一。这些微量药物,尤其是UTX-44,对RLM脂质过氧化的抑制活性也比trolox高得多。这些结果表明,UTX-44在这些药物中具有最有效的含硼抗氧化剂。

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