The FEAST trial of fluid bolus in African children with severe infection - Authors' reply

摘要

I think the FEAST Trial Group might have misunderstood some of my comments. I did notsaythatthe results could not be extrapolated to children with "shock" in their setting. I agree with Kathryn Maitland and colleagues that they can be. What I said was: "The main message-fluid boluses are dangerous in children with malaria, and in other common febrile illnesses in which ADH secretion is likely to be high-is important to disseminate clearly" and "This trial does not inform about the management of other shock conditions: dengue shock syndrome in Asia, or hypovolaemic shock from diarrhoea and vomiting. Nor does it clarify the management of bacteraemic shock with hypotension in countries outside Africa, but it does give pause for thought"