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首页> 外文期刊>The Lancet >Developmental dysplasia of the hip.
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Developmental dysplasia of the hip.

机译:髋部发育不良。

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In its severest form, developmental dysplasia of the hip is one of the most common congenital malformations. The pathophysiology and natural history of the range of morphological and clinical disorders that constitute developmental dysplasia of the hip are poorly understood. Neonatal screening programmes, based on clinical screening examinations, have been established for more than 40 years but their effectiveness remains controversial. Whereas systematic sonographic imaging of newborn and young infants has afforded insights into normal and abnormal hip development in early life, we do not clearly understand the longer-term outcomes of developmental hip dysplasia, its contribution to premature degenerative hip disorders in adult life, and the benefits and harms of newborn screening. High quality studies of the adult outcomes of developmental hip dysplasia and the childhood origins of early degenerative hip disease are needed, as are randomised trials to assess the effectiveness and safety of neonatal screening and early treatment.
机译:在最严重的形式中,髋部发育不良是最常见的先天性畸形之一。人们对构成髋关节发育不良的形态学和临床疾病范围的病理生理学和自然病程知之甚少。基于临床筛查检查的新生儿筛查计划已经建立了40多年,但其有效性仍存在争议。尽管新生儿和幼儿的系统超声影像学可以洞悉早期髋关节的正常和异常发育,但我们仍不清楚发育性髋关节发育不良的长期结局,其对成年期髋关节退行性变性的贡献以及新生儿筛查的利弊。需要高质量的研究来评估成人发育性髋关节发育不良和早期退行性髋关节疾病的童年起源,以及评估新生儿筛查和早期治疗的有效性和安全性的随机试验。

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