Re: Towards the definition of the best management and prognostic factors of teratoma with malignant transformation: A single-institution case series and new proposal

摘要

Objective: To investigate the optimal management and prognostic factors of patients with malignant transformation (MT) in germ-cell tumour (GCT) by re-evaluating Institutional series. Patients and Methods: Patients with an MT within GCT have been identified from the institutional database and all slides have been reviewed by the referral pathologist. Eesults: From June 1982 to October 2009, 48 patients and 13 somatic histologies have been identified. Twelve patients presented with stage 1,12 with stage II and 24 with stage III disease. All stage I patients are alive and disease-free after a median follow up of 88 months (interquartile range 38-103). Of the 36 metastatic cases, 11 underwent GCT-oriented chemotherapy plus surgery and seven of them are currently disease-free. Three patients underwent MT-chemotherapy, one relapsed and is still under treatment. Overall, 17 patients relapsed (35%) and three of them have been rescued by GCT-chemo-therapy.