Re: Small prostate size and high grade disease--biology or artifact?: J. J. Liu, J. D. Brooks, M. Ferrari, R. Nolley and J. C. Presti, Jr. J Urol 2011; 185: 2108-2111.

摘要

I read this article with great interest. The authors determined that small prostate size itself may not be a predictor of high grade disease, but rather the association between small prostate size and high grade disease may be a consequence of the performance characteristics of prostate specific antigen (PSA).I have some points of concern with this study. First, the authors classified the cases as Tic and T2. Median prostate weight was determined in each group. If the hypothesis is that prostate size predicts high grade prostate cancer, the cases must be classified according to prostate volume (PV). If cases with other pathological stages were added to the study, it could be more objective.Another point is the prognostic parameters of radical prostatectomy (RP) specimens.