Re: Ureteral and multifocal tumours have worse prognosis than renal pelvic tumours in urothelial carcinoma of the upper urinary tract treated by nephroureterectomy

摘要

Background: It is not known whether the primary tumour location of upper urinary tract urothelial carcinoma (UUT-UC) is associated with prognosis. Objective: To evaluate the impact of initial primary tumour location on survival in patients who had undergone radical nephroureterectomy (RNU). Design, Setting, and Participants: Using a multi-institutional, retrospective database, we identified 609 patients with UUT-UC who had undergone RNU between 1995 and 2010. Tumour location was categorised as renal pelvis, ureter, or multifocal. Intervention: All patients had undergone RNU. Measurements: Tumour location was tested as a prognostic factor for survival through univariate and multivariable Cox regression analysis. Results and Limitations: Tumour location was renal pelvis in 317 cases (52%), ureter in 185 cases (30%), and multifocal in 107 cases (18%).