Silver(I)-Catalyzed Tandem Sigamatropic Rearrangement/1,3-H Shift/6 pi Aza-electrocyclization of N-Propargylic Hydrazones: A Mild Synthetic Route to 1,6-Dihydropyridazines

摘要

A highly efficient AgOTf catalyzed [3,3] sigmatropic rearrangement/1,3-H shift/6 pi aza-electrocyclization cascade reaction of N-propargylic hydrazones has been developed. This method provides a new mild synthetic route to various polysubstituted 1,6-dihydropyridazines including the 3-CF3-substituted ones with high selectivity.