Palladium-Catalyzed Intramolecular Oxidative Coupling Involving Double C(sp~2)?H Bonds for the Synthesis of Annulated Biaryl Sultams

摘要

The palladium-catalyzed intramolecular oxidative coupling described herein involves a double C(sp~2)?H bond functionalization in sulfonanilides, providing a workable access to biaryl sultams annulated into a six-membered ring that are otherwise difficult to obtain by literature methods. The other synthetic applications of this protocol including the synthesis of biaryl sultams containing a seven-membered ring and analogous sultones are also presented.