Lewis Acid Template-Catalyzed Asymmetric Diels-Alder Reaction

摘要

An asymmetric DielsAlder reaction of 2,4-dienols and methyl acrylate utilizing a chiral Zn(II)/Mg(II) bimetallic template with low catalyst loading was successfully achieved. The bimetallic Lewis acid template derived from (R)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2-naphthol catalyzed the DielsAlder reaction in the presence of molecular sieves 4 angstrom to afford various functionalized bicyclic gamma-lactones with high enantiomeric purities.