Hydrogen peroxide (H2O2) affects biological processes by producing cellular signaling to regulate redox reactions in live cells. By redox signaling, Cytochrome C (Cyt C) in mammalian cells is especially distinguishable for H2O2 in controlling ion transportation in biological ion channels. To mimic the mechanism for redox-driven in biology, we modified Cyt C, which could bind H2O2, on polymer conical nanochannels to form a redox-driven nanosystem. The influence of the different H2O2 concentrations on the ion transportation property in the redox-driven nanosystem is investigated and discussed. The theoretical model of this nanosystem based on the Poisson and NernstPlanck equations is in good agreement with the experimental data. Accordingly, we constitute a biomimetic reversible and repeatable redox-driven smart nanogating system, monitoring the ion transportation process.
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