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The heterogeneous biomechanics and mechanobiology of the mitral valve: implications for tissue engineering.

机译:二尖瓣的异质生物力学和力学生物学:对组织工程的影响。

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摘要

There are compelling reasons to develop a tissue-engineered mitral valve, but this endeavor has not received the same attention as tissue engineering strategies for the semilunar valves. Challenges in regenerating a mitral valve include recapitulating the complex heterogeneity in terms of anatomy (differently sized leaflets, numerous chordae), extracellular matrix composition, biomechanical behavior, valvular interstitial cell and endothelial cell phenotypes, and interior vasculature and innervation. It will also be essential to restore the functional relationships between the native mitral valve and left ventricle. A growing amount of information relevant to tissue engineering a mitral valve has been recently collected through investigations of cell mechanobiology and collagen organization. It is hoped that the development of tissue-engineered mitral valves can build on knowledge derived from engineering semilunar valves, but the mitral valve will present its own unique challenges as investigators move toward a first-generation prototype.
机译:有充分的理由来开发组织工程二尖瓣,但是这种努力并未得到与半月瓣组织工程策略同样的关注。再生二尖瓣的挑战包括在解剖学上重新概括复杂的异质性(不同大小的小叶,许多腱索),细胞外基质组成,生物力学行为,瓣膜间质细胞和内皮细胞表型以及内部脉管和神经支配。恢复天然二尖瓣和左心室之间的功能关系也必不可少。最近,通过对细胞力学生物学和胶原蛋白组织的研究,收集了与二尖瓣组织工程相关的越来越多的信息。希望组织工程二尖瓣的开发可以基于从工程半月瓣得到的知识,但是随着研究人员朝着第一代原型发展,二尖瓣将面临其自身的独特挑战。

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