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Ordinary differential equation for local accumulation time

机译:局部累积时间的常微分方程

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Cell differentiation in a developing tissue is controlled by the concentration fields of signaling molecules called morphogens. Formation of these concentration fields can be described by the reaction-diffusion mechanism in which locally produced molecules diffuse through the patterned tissue and are degraded. The formation kinetics at a given point of the patterned tissue can be characterized by the local accumulation time, defined in terms of the local relaxation function. Here, we show that this time satisfies an ordinary differential equation. Using this equation one can straightforwardly determine the local accumulation time, i.e., without preliminary calculation of the relaxation function by solving the partial differential equation, as was done in previous studies. We derive this ordinary differential equation together with the accompanying boundary conditions and demonstrate that the earlier obtained results for the local accumulation time can be recovered by solving this equation.
机译:发育中组织的细胞分化受称为吗啡生成物的信号分子的浓度场控制。这些浓度场的形成可以通过反应扩散机理来描述,其中局部产生的分子扩散通过图案化的组织并降解。在图案化组织的给定点处的形成动力学可以通过局部累积时间来表征,该累积时间根据局部松弛函数来定义。在这里,我们表明这次满足一个常微分方程。使用该方程式可以直接确定局部累积时间,即,无需像先前的研究那样通过求解偏微分方程式来预先计算松弛函数。我们推导了该常微分方程及其伴随的边界条件,并证明了通过求解该方程可以恢复较早获得的局部累积时间的结果。

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