A mild and efficient method for one-step alpha-haloacetalization of acetophenones using 1,3-dihalo-5,5-dimethylhydantoin in ethylene glycol

摘要

A mild and efficient method that could directly prepare alpha-haloacetal acetophenones from various acetophenones with 1,3-dihalo-5,5-dimethylhydantoin (DBDMH/DCDMH) and ethylene glycol in good yields without catalysts was reported. The effects of solvents, 1,3-dihalo-5,5-dimethylhydantoin, and reaction temperature were investigated. Under the optimal condition, most of a-haloacetal acetophenones were obtained in 65-97% yields. (C) 2015 Elsevier Ltd. All rights reserved.