Gold(I)catalyzed sequential cycloisomerization/bis-addition of o-ethynylanilines:an efficient access to bis(indolyl)methanes and di(indolyl)indolin-2-ones

摘要

An efficient synthesis of bis(indolyl)methanes and di(indolyl)indolin-2-ones have been developed by a sequential approach involving gold(I)catalyzed cycloisomerization/bis-addition of o-ethynylanilines with various aldehydes and isatins respectively.This methodology opens clean and synthetically competitive alternative to the already established procedures of the synthesis of bis(indolyl)methanes and di(indolyl)indolin-2-ones.