The biosynthesis of sorbicillinoids in Trichoderma sp.USF-2690:prospect for the existence of a common precursor to sorbicillinol and 5-epihydroxyvertinolide,a new sorbicillinoid member

摘要

Biosynthetic feeding studies of[1-~(13)C],[2-~(13)C],and[1,2-~(13)C2]-labeled sodium acetates into 5-epihydroxyvertinolide,a new sorbicillinoid,gives an incorporation pattern that proves the gamma-lactone ring formation associated with a ring cleavage reaction of the precursor,a potential intermediate of sorbicillinol biosynthesis.