A facile and catalytic method for selective deprotection of tert-butyldimethylsilyl ethers with copper(II) bromide

摘要

Copper(H) bromide is found to be a simple and efficient catalyst for selective deprotection of tert-butyidimethylsilyl ethers of alcohols/phenols at ambient temperature. Various labile functional groups such as ketal, alkene, ketone, OTBDPS, OTHP and allyl and benzyl ethers are found to be compatible under the reaction conditions. (c) 2006 Elsevier Ltd. All rights reserved.