Karatungiols A and B,two novel antimicrobial polyol compounds,from the symbiotic marine dinoflagellate Amphidinium sp.

摘要

Karatungiols A (1)and B (2),two novel antimicrobial polyol compounds,were isolated from the cultivated symbiotic marine dinoflagellate Amphidinium sp.Their structures were elucidated based on spectroscopic analysis and degradation reactions.Karatungiols A (1)and B (2)consisted of a C69-linear chain with a ketone moiety,24 or 25 hydroxyl groups,and two tetrahydro-pyran rings.Karatungiol A (1)exhibited antifungal activity against Aspergillus niger at 12 mug/disc and antiprotozoan activity against Trichomonas foetus at 1 mug/ml.