Enantioselective reactions of tert-butyl glycinate-benzophenone Schiff base catalyzed by chiral phase-transfer catalyst in aqueous media without any organic solvent

摘要

Chiral phase-transfer catalyzed enantioselective alkylations of tot-butyl glycinate-benzophenone Schiff base were investigated in aqueous media without any organic solvent.Reactions in aqueous media smoothly proceeded to give the desired product in higher yield than under standard liquid-liquid biphasic conditions.In aqueous media the formation of benzophenone,which was caused by in situ hydrolysis of Schiff base,was depressed.