Efficient preparation of (Z)-alkenyl derivatives from (Z)-vinyl (N,N-diisopropyl)carbamate via Ni=catalysed coupling reactions

摘要

A (Z)-vinyl (N,N-diisopropyl)carbamate treated with Grignard reagents,under Wenkert Nickel-catalysed conditions,gave access to several substituted (Z)-alkenyl derivatives.These Nickel-catalysed reactions,carried out with vinyl-,phenyl-,p-methoxyphenyl,trimethlsilylmethylmagnesium bromide and benzylmagnesium chloride,led to the corresponding (Z)-alkenyl derivatives in good yields and high stereoselectivities.