Hydroxylamines an dsulfinamide as amine components in the Petasis boronic acid-Mannich reaction:synthesis of N-hydroxy or alkoxy-alpha-aminocarboxylicacids and N-(tert-butyl sulfinyl)-alpha-amino carboxylicacids

摘要

An efficient synthesis of N-hydroxy or alkoxy-alpha-aminocarboxylic acids and N-(tert-butyl sulfinyl)-alpha-amino carboxylic acids has been developed from N,O-alkyl or hydroxylamies and tert-butyl sulfinamide utilizing a petasis boronic acid-Mannich reaction.The scope and limitations of this method have been examiend.