Asymmetric synthesis of cetirizine dihydrochloride

Derek A.Pflum; Dhileepkumar Krishnamurthy; Zhengxu Han; Stephen A.Wald; Chris H.Senanayake

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Asymmetric synthesis of cetirizine dihydrochloride

机译：盐酸西替利嗪的不对称合成

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Practical route technology for the preparation of (S0-cetiizine·2HCl via diastereoselective organometallic addition to N-tert-butanesulfinyl aldimines is disclosed.

机译：公开了通过将非对映选择性有机金属加成到N-叔丁亚磺酰亚胺基亚胺上来制备（S0-西替齐嗪·2HCl）的实用路线技术。

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《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |2002年第6期|共4页
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Derek A.Pflum; Dhileepkumar Krishnamurthy; Zhengxu Han; Stephen A.Wald; Chris H.Senanayake;
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1. Asymmetric synthesis of cetirizine dihydrochloride [J] . Derek A.Pflum, Dhileepkumar Krishnamurthy, Zhengxu Han, Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2002,第6期

机译：盐酸西替利嗪的不对称合成
2. A Scalable Asymmetric Synthesis of (R)-2-Amino-1-(3-pyridinyl)ethanol Dihydrochloride via an Oxazaborolidine Catalyzed Borane Reduction [J] . Jason Duquette, Mingbao Zhang, Lei Zhu, Organic process research & development . 2003,第3期

机译：恶唑硼烷催化的硼烷还原反应可分级不对称合成（R）-2-氨基-1-（3-吡啶基）乙醇二盐酸盐
3. An asymmetric synthesis of the novel H-3 agonist (+)-(3R,4R)-3-(4-imidazolyl)-4-methylpyrrolidine dihydrochloride (Sch 50971) [J] . Aslanian R., Iyer RV., Shih NY., Tetrahedron, Asymmetry: The International Journal for Repid Publication on all Aspects of Asymmetry in Orgainc, Inorganic, Organometallic, Physical and Bio-Organic Chemistry . 2000,第19期

机译：新型H-3激动剂（+）-（3R，4R）-3-（4-咪唑基）-4-甲基吡咯烷二盐酸盐的不对称合成（Sch 50971）
4. In-Vitro Transdermal Permeation Comparison of Cetirizine Base vs. Cetirizine Dihydrochloride [C] . Samara Hantman, Somi Bonne, David Houze, Controlled Release Society Annual Meeting and Exposition . 2007

机译：西替利嗪碱与西替利嗪二盐酸盐的体外透皮渗透比较
5. Part I. One-pot synthesis of secondary alcohols and one-pot asymmetric synthesis of secondary propargylic alcohols. Part II. Redox isomerization of secondary propargylic alcohols to enones. Part III. Synthesis study towards C9-C14 fragment of (+)-discodermolide. Part IV. Asymmetric synthesis of anti, anti-stereotriad building blocks for polypropionate natural products [D] . Xie, Qiuzhe 2007

机译：第一部分：仲醇的一锅法合成和仲炔丙醇的一锅法不对称合成。第二部分仲炔丙醇的氧化还原异构化为烯酮。第三部分（+）-discodermolide C9-C14片段的合成研究。第四部分聚丙烯酸酯天然产物的抗，抗立体三环构建基的不对称合成
6. Taste-masking assessment of orally disintegrating tablets and lyophilisates with cetirizine dihydrochloride microparticles [O] . Aleksandra Amelian, Katarzyna Wasilewska, Małgorzata Wesoły, 2017

机译：西替利嗪二盐酸盐微粒对口腔崩解片和冻干品的掩味评估
7. Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride [O] . Krisztián Pamlényi, Katalin Kristó, Orsolya Jójárt-Laczkovich, 2021

机译：含藻酸钠聚合物薄膜作为含有环氮含义的颊粘膜粘附药物递送系统的配制和优化

Asymmetric synthesis of cetirizine dihydrochloride

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