Tandem allylic amination/ring-opening/oxa-Michael addition reactions of chromone-derived Morita-Baylis-Hillman acetates with amines

摘要

The reaction of chromone-derived Morita-Baylis-Hillman acetates with amines was developed via tandem allylic amination/chromone ring-opening/oxa-Michael addition to provide 2-substituted-3-aminomethy-lene-chromans in convenient and efficient way, and subsequent applied in the synthesis of benzopyranylpyrimidine compounds. Various amines exhibited different reactivities depending on their molecular structural characteristics.