A facile and efficient method for the synthesis of novel pyridone analogues by aminolysis of an ester under solvent-free conditions

摘要

A series of 15 pure novel N-alkylated pyridone derivatives have been synthesized in 73–96% yields on treatment of ethyl (2-pyridone)acetates with structurally diverse amines in an efficient aminolysis procedure under ‘solvent-free’ conditions.