The microbiological transformation of steroidal saponins by Curvularia lunata

摘要

The microbiological transformation of polyphyllin I (compound I), polyphyllin III (compound II), polyphyllin V (compound 111) and polyphyllin VI (compound IV) by Curvularia lunata into their corresponding subsaponins, for example, diosgenin-3-O-alpha-L-arabinofuranosyl (1 -> 4)-beta-D-glucopyranoside (compound V), diosgenin-3-O-alpha-L-rhamnopyranosyl (1 -> 4)-beta-D-glucopyranoside (compound VI), diosgenin-3-0-0-D-glucopyranoside (compound VII) and pennogenin-3-O-beta-D-glucopyranoside (compound VIII), were studied in this paper. Curvularia lunata is able to hydrolyze terminal rhamnosyls that are linked by 1 -> 2 C- bond to sugar residues of steroidal saponins at C-3 position with high activity and regioselectivity. (c) 2005 Elsevier Ltd. All rights reserved.