Synthesis and interfacial properties of amphiphilic beta-cyclodextrins and their substitution at the 0-6 position with a mono bio-recognisable galactosyl antenna

摘要

The synthesis of a mono-galactosylated amphiphilic beta-cyclodextrin, in five steps from mono-6-azido-6-deoxy-beta-cyclodextrin, via coupling to a N-beta-D-galactopyranosylamino-antenna is described. Both characterization by electrospray mass spectrometry and NMR show the presence of only the mono-substituted product. The Langmuir isotherms of the final product and intermediates are described. (c) 2005 Elsevier Ltd. All rights reserved.