Rakanmakilactones A-F, new cytotoxic sulfur-containing norditerpene dilactones from leaves of Podocarpus macrophyllus var. maki

摘要

Six new S-containing norditerpene dilactones, rakanmakilactones A-F (5-10), were isolated from the leaves of Podocarpus macrophyllus D. Don var. maki Endl., along with four known norditerpene dilactones (1-4). Their structures, stereochemistry and absolute configurations were determined by spectroscopic studies (HRMS, IR, H-1, C-13 and 2D NMR), and single-crystal X-ray analyses. Rakanmakilactones were found to have a cytotoxic effect against P388 murine leukemia cells. (C) 2003 Elsevier Ltd. All rights reserved. [References: 19]