On the origin of the phase-space diffusion limit in (dis)ordered protein aggregation This study is dedicated to commemorate the achievements of Prof. Jan Czochralski (1885-1953), an outstanding crystal grower, on the official occasion of the year 2013 as the year devoted in Poland to His scientific heritage.

摘要

Derivation of a phase-space diffusion limit (D-L) allows to obtain a useful formula for a characteristic width of the macroion-channeling filter, controlling model (dis)ordered protein aggregations in a non-ideal aqueous solution. The channel's width is estimated at the order of an inner half-width of the Stern-type double layer circumventing the growing object and depends in turn on an interplay of the local thermal and electrostatic conditions. The interfacial channeling effect manifests at the edge of biomolecular hydration-duration dependent (non)Markovianity of the system. The interface vs. solution aggregation late-time dynamics are discussed in such local (non)isothermal context with the aim to suggest their experimental assessment.