Interaction of Sodium Bicarbonate and Na+/H+ Exchanger Inhibition in the Treatment of Acute Metabolic Acidosis in Pigs

摘要

Objective: Administration of NaHco(3) does not improve cellular function or reduce the mortality of acute lactic acidosis. This might be related to aggravation of intracellular acidosis, but it could also be due to activation of Na+/H+ exchanger with a deleterious increment in intracellular calcium ([Ca2+](i)). This study examined the impact of coadministration of NaHco(3) and a selective inhibitor of Na+/H+ exchanger, sabiporide on cardiovascular function, changes in proinflammatory cytokines, and organ function in a model of acute lactic acidosis produced by hemorrhagic hypotension followed by infusion of lactic acid.