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首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Effects of acupuncture on abdominal leak point pressure and c-Fos expression in the brain of rats with stress urinary incontinence.
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Effects of acupuncture on abdominal leak point pressure and c-Fos expression in the brain of rats with stress urinary incontinence.

机译:针刺对应激性尿失禁大鼠大脑腹漏点压力和c-Fos表达的影响。

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摘要

Stress urinary incontinence leads to the involuntary loss of urine during abdominal strain caused by sneezing, laughing, and coughing. Acupuncture has been widely used for the treatment and prevention of a variety of diseases in traditional medicine. Acupuncture has also been used to relieve the symptoms of functional disorders of the lower urinary tract. In the present study, we investigated the effect of acupuncture at the Sanyinjiao (SP6) acupoint on stress urinary incontinence in rats. The present results showed that abdominal leak point pressure was decreased in rats with stress urinary incontinence, while acupuncture at the SP6 acupoint significantly enhanced the abdominal leak point pressure. The expression of c-Fos in the pontine micturition center (PMC), ventrolateral periaqueductal gray (vlPAG), and medial preoptic nucleus (MPA) regions was increased by the induction of stress urinary incontinence, and acupuncture at the SP6 acupoint significantly decreased c-Fos expression in these areas. Inthe present study, we showed that acupuncture has therapeutic effect on the symptoms of stress urinary incontinence, and this effect of acupuncture is associated with modulation of c-Fos expression in the brain.
机译:压力性尿失禁会导致因打喷嚏,大笑和咳嗽而导致腹部劳损时尿液不自主流失。针灸已被广泛用于传统医学中各种疾病的治疗和预防。针灸也已用于缓解下尿路功能障碍的症状。在本研究中,我们研究了针刺三阴交穴(SP6)对大鼠压力性尿失禁的影响。目前的结果表明,应激性尿失禁大鼠的腹漏点压力降低,而SP6穴位的针刺显着增强了腹漏点压力。压力性尿失禁的诱导增加了脑桥排尿中心(PMC),腹外侧导水管周围灰色(vlPAG)和内侧视前核(MPA)区c-Fos的表达,针刺SP6穴位显着降低了c-Fos这些地区的Fos表达。在本研究中,我们表明针灸对应激性尿失禁的症状具有治疗作用,而针灸的这种作用与脑中c-Fos表达的调节有关。

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