Cancer therapy improvement with mesoporous silica nanoparticles combining photodynamic and photothermal therapy

摘要

In this work, we develop novel mesoporous silica composite nanoparticles (hm-SiO_2 (AlC_4 Pc) @Pd) for the co-delivery of photosensitizer (PS) tetra-substituted carboxyl aluminum phthalocyanine (AlC_4 Pc) and small Pd nanosheets as a potential dual carrier system to combine photodynamic therapy (PDT) with photothermal therapy (PTT). In the nanocomposite, PS AlC_4 Pc was covalently conjugated to a mesoporous silica network, and small Pd nanosheets were coated onto the surface of mesoporous silica by both coordination and electrostatic interaction. Since small Pd nanosheets and AlC_4 Pc display matched maximum absorptions in the 600 - 800 nm near-infrared (NIR) region, the fabricated hm-SiO_2 (AlC_4 Pc)@Pd nanocomposites can generate both singlet oxygen and heat upon 660 nm single continuous wavelength (CW) laser irradiation. In vitro results indicated that the cell-killing ef ? cacy by simultaneous PDT/PTT treatment using hm-SiO_2 (AlC_4 Pc)@Pd was higher than PDT or PTT treatment alone after exposure to a 660 nm CW-NIR laser.