Poly(N-vinylpyrrolidone) bearing covalently attached cyclodextrin via click-chemistry: Synthesis, characterization, and complexation behavior with phenolphthalein

摘要

We report about modification of poly(N-vinylpyrrolidone) (PVP) with monofunctional β-cyclodextrin (βCD) via click-chemistry. The modification was carried out by copper(I)-catalyzed microwave-assisted Huisgen-type cycloaddition of 3-propargyl-N-vinylpyrrolidone (2a) and mono(6-azido-6-deoxy)-β-cyclodextrin (3). We synthesized a copolymer (5) carrying CD moieties which has the same composition as the applied molar ratio of monomers. Complexation experiments of the obtained polymer (5) with phenolphthalein (PP) showed alower binding constant comparedtoβCD causedbysterical effects of the polymer coil.