1,3-Dipolar Cycloaddition of Azomethine Ylides Involving 3-Aminooxindoles: Versatile Construction of Dispiro[pyrrolidine-2,3 '-oxindole]Scaffolds

摘要

A three-component [3+2] cycloaddition involving 3-aminooxindoles, aldehydes, and methyleneindolinone derivatives for the synthesis of dispiro[pyrrolidine-2,3'-oxindole] derivatives was developed. This reaction involves the use of readily available starting materials and mild reaction conditions. It displays broad functional-group tolerance and provides the products in high yields with good to excellent diastereoselectivities.