Palladium-Catalyzed Regioselective Dehydrogenative C-H/C-H Cross-Coupling of Pyrroles and Pyridine N-Oxides

摘要

The palladium-catalyzed cross-dehydrogenative coupling of N-alkylpyrroles and pyridine N-oxides gave the corresponding pyrrolylpyridine N-oxides. Cu(OAc)(2)H2O as a co-catalyst with air as the terminal oxidant led to preferential coupling in the -position, whereas AgOAc as the stoichiometric oxidant resulted in preferential coupling in the -position. N-(Benzyloxymethyl)pyrrole derivatives were deprotected by hydrogenolysis followed by basic hydrolysis.