Swimming reduces the severity of physical and psychological dependence and voluntary morphine consumption in morphine dependent rats

摘要

Previous studies have indicated that voluntary exercise decreases the severity of the anxiogenic-like behaviors in both morphine-dependent and withdrawn rats. This study examined the effects of regular swimming exercise during the development of dependency and spontaneous morphine withdrawal on the anxiety-depression profile and voluntary morphine consumption in morphine dependent rats. The rats were chronically treated with bi-daily doses (10 mg/kg, at 12 h intervals) of morphine over a period of 14 days. The exercising rats were allowed to swim (45 min/d, five days per a week, for 14 or 21 clays) during the development of morphine dependence and withdrawal. Then, rats were tested for the severity of morphine dependence, the elevated plus-maze (EPM), sucrose preference test (SPT) and voluntary morphine consumption using a two-bottle choice paradigm in animal models of craving. The results showed that withdrawal signs were decreased in swimmer morphine dependent rats than sedentary rats (P < 0.05). Also, the swimmer morphine-dependent and withdrawn rats exhibited an increase in [PM open arm time and entries (P < 0.05), higher levels of sucrose preference (P < 0.001) than sedentary rats. Voluntary consumption of oral morphine was less in the swimmer morphine withdrawn rats than the sedentary groups during four periods of the intake of drug (P < 0.01). We conclude that regular swimming exercise reduces the severity of morphine dependence and voluntary morphine consumption with reducing anxiety and depression in morphine dependent and withdrawn rats. Thus, swimming exercise may be a potential method to ameliorate some of the deleterious behavioral consequences of morphine dependence. (C) 2014 Elsevier B.V. All rights reserved.