in vitro Evaluation of Zeolite Nanoparticles as Carrier for Delivery of 5-Fluorouracil

摘要

The aim of the work is to evaluate the use of zeolite ZSM-5 nanoparticles for loading and release of 5-fluorouracil. Nanoparticles of zeolite ZSM-5 with different SiO2/Al2O3 ratios have been prepared in both the sodium and acid form. All nanoparticle samples of ZSM-5 were loaded with the model anticancer drug 5-fluorouracil. The loaded and unloaded nanoparticle samples were characterized by XRD. SEM, TGA and FTIR. Loading of ZSM-5 samples was performed in an aqueous saturated solution of 5-fluorouracil. A loading greater than 50 % was achieved for the acid-activated nanopatricles of ZSM-5 with a SiO2/Al2O3 ratio of 30 (in the starting gel). The release experiments were conducted in simulated body fluid at a pH of 7.4 and 37 °C. In general, the acid-activated nanoparticles of ZSM-5 show higher percent loading, lower percent release and smaller first order rate constant than the corresponding non-activated samples.