Volumetric and Thermodynamic Study of Three Pharmacologically Important Drugs in Ethanol

摘要

In this manuscript, the determination of different parameters for the calculation of different types of interaction of three drugs in ethanol is reported. The drugs used are chlorpheniramine maleate, levofloxacin and chloramphenicol. The density measurements of these drugs in ethanol at four different temperatures were used to calculate apparent molar volume, partial molar volume at infinite dilution, Hepler's constant, partial molar expansivity constant and isobaric thermal expansion coefficient. All the required parameters were calculated by measuring the density of solutions of different concentrations in ethanol at four different temperatures i.e. 288, 298, 308 and 318 K. The values of these parameters showed the presence of solvophilic interaction in case of chlorpheniramine maleate and solvophobic for other two drugs. There was also found to exist structure promoting effect of levofloxacin and chloramphenicol on ethanol solvent while structure breaking effect due to chlorpheniramine maleate.