The Use of a Triple-Drug Combination Product for the Treatment of Postinflammatory Hyperpigmentation

摘要

Postinflammatory hyperpigmentation (PIH) is a common pigmentary disorder seen in people with skin of color. Although the pathophysiology of PIH remains unknown, various inflammatory mediators released by inflammatory cells in the dermis interact with epidermal keratinocytes and melanocytes to cause this disorder.The objective of therapy is to address the underlying inflammation as well as excessive melanogenesis through the use of pharmacologic agents and procedures such as chemical peels and laser surgery. Combination pharmacologic therapy is optimal in addressing the underlying inflammation and changes in the epidermal cells and melanocytes that occur in PIH.The case report presented in this article demonstrates the efficacy of a triple-drug combination product (fluocinolone acetonide 0.01%, hydroquinone 4.0%, tretinoin 0.05%) in resolving PIH in a patient with skin of color and contributing to the management of the patient's acne vulgaris.