Serotype distribution and antimicrobial resistance of invasive pneumococcal disease strains in the Comunidad Valenciana, Spain, during the winter of 2009-2010: Low PCV7 coverage and high levofloxacin resistance

摘要

treptococcus pneumoniae can cause serious invasive pneumo-coccal diseases (IPD), such as pneumonia, sepsis, and meningitis, and is the cause of major morbidity and mortality worldwide. The bacterium produces a capsule, of which over 90 serotypes exist and which forms the basis of the current conjugate vaccines (5). Since the introduction of the pneumococcal conjugate vaccine (PCV7) that protects against 7 serotypes (4, 6B, 9V, 14, 18C, 19F, and 23F), a shift in IPD-causing serotypes toward nonvaccine serotypes has been observed worldwide (2, 4, 10).