First detection of trimethoprim resistance determinant dfrG in Streptococcus pyogenes clinical isolates in India

摘要

Streptococcus pyogenes is capable of causing a wide spectrum of diseases, ranging from throat and skin infection to life-threatening invasive diseases (2). The sequelae of streptococcal infections, such as acute rheumatic fever, represent a big health hazard (1). Recently, the emergence of invasive streptococcal diseases in India has been reported (5). Streptococcal emm types of the Indian subcontinent differ from those of other countries (7, 8). emml, which is one of the most prevalent invasive types of Western countries, is rare in India. Instead, another type, designated emml-2, is prevalent in India (8), and a subtype, emml-2.2, is associated with invasive disease (5).