Direct Arylation of 6-Phenylpurine and 6-Arylpurine Nucleosides by Ruthenium-Catalyzed C-H Bond Activation

摘要

C-H bond activation represents an efficient approach to molecular functionalization. In directed C-H bond activation, Lewis basic sites are exploited to draw the catalyst proximal to the reactive center. We have been interested in the C-H bond activation and arylation of nucleobases and nucleosides using the nitrogen atoms of the purine itself as the Lewis basic sites.